The existence of “Marijuana” has been in our culture for centuries. There is no difference between the cannabis and marijuana. They generally mean the same; the two terms label the same thing. The usage of cannabis can be traced as far back as the pre pottery Neolithic (8800-6500 BCE)—based on archaeological evidence. “Marijuana” was used before “weed”. It became popular in 1910 while weed came later in vogue in early 1930’s. The initial restrictions ever known on cannabis were reported in the Islamic world by 14th century followed by 19th century restrictions in colonial countries which were associated with racial and class strains. From 20th century, growing International coordination led to sweeping restrictions on cannabis throughout the globe while entering the 21st century, nations began to regulate and decriminalize cannabis. This paper focuses on the use of marijuana as food, medicine, psychoactive properties for recreational and religious purposes and also to realize if countries can make a choice to legalize or illegalize.